Sumit K Basu

This article reviews current knowledge concerning cardiovascular disease in subjects with (and without) diabetes mellitus. It discusses the worldwide distribution and dimensions of these disorders. It contrasts incidence, prevalence, investigations, treatment strategies and outcomes of coronary heart disease and myocardial infarction amongst patients with and without diabetes. Emphasis is given to discussing the outcomes of various trials of treatments and management strategies applied to such patients and how closely they apply to the diabetic cohorts who constitute a substantial proportion of most of those trials. The article concludes with a review of specific treatments for elevated glucose which may have prognostic benefits in CVD.